𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and biological activity of a cyclic hexapeptide fromDianthus superbus

✍ Scribed by Rajiv Dahiya

Book ID
111491165
Publisher
Versita
Year
2008
Tongue
English
Weight
324 KB
Volume
62
Category
Article
ISSN
0366-6352

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Plant-originated cyclopolypeptide (XIII) was synthesized by coupling of dipeptide Boc-l-asn(bzh)-l-phe-OH and tetrapeptide gly-l-leu-l-ala-l-tyr-OMe followed by cyclization of a linear hexapeptide segment. Structure elucidation of XIII was done on basis of detailed spectral analysis including FTIR, 1H NMR, 13C NMR, FAB MS and elemental analysis. From the results of pharmacological screening, it was concluded that XIII possesses high cytotoxic activity against DLA and EAC cell lines with CTC50 values of 15.1 ΞΌM and 18.6 ΞΌM, and potent antimicrobial activity against pathogenic fungi C. albicans with MIC of 6 ΞΌg mLβˆ’1. Moreover, XIII possesses moderate anthelmintic activity against earthworms M. konkanensis, P. corethruses, and Eudrilus sp. at 2 mg mLβˆ’1 dose level.

πŸ“œ SIMILAR VOLUMES

Transition metal complexes of a cyclic p
Transition metal complexes of a cyclic pseudo hexapeptide: synthesis, complex formation and catalytic activities
✍ Huong Ngyen; Marit Orlamuender; David Pretzel; Inge Agricola; Ulrich Sternberg; πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 314 KB

## Abstract To contribute to a better understanding of metalloenzymes, we studied ion selectivity, complex formation tendencies and catalytic activities of linear and cyclic pseudopeptides. In this contribution, a linear and cyclic pseudo hexapeptide is described. The complex with transition metal