Synthesis and biological evaluation of 3
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Yisheng Lai; Lin Ma; Wenxing Huang; Xing Yu; Yihua Zhang; Hui Ji; Jide Tian
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Article
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2010
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Elsevier Science
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English
⚖ 424 KB
Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I