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Synthesis and biological activity of 4-aryl-3-benzoyl-5-phenylspiro[pyrrolidine-2.3′-indolin]-2′-one derivatives as novel potent inhibitors of advanced glycation end product

✍ Scribed by Kaur, Anjandeep; Singh, Baldev; Vyas, Bhawna; Silakari, Om


Book ID
121803723
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
908 KB
Volume
79
Category
Article
ISSN
0223-5234

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Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I