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Synthesis and Biological Activity of 3,4-Dihydroquinazolines for Selective T-Type Ca2+ Channel Blockers.

✍ Scribed by Hyewhon Rhim; Yong Sup Lee; Seong Jun Park; Bong Young Chung; Jae Yeol Lee


Publisher
John Wiley and Sons
Year
2005
Weight
22 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract Low‐voltage‐activated (LVA) Ca^2+^ channels play a critical role in the generation of burst firing in the thalamus. Recently, three LVA Ca^2+^ channel isoforms (Ca~v~3.1, Ca~v~3.2, Ca~v~3.3) have been identified in the reticular thalamic nucleus (RE). Previous electrophysiological and m