✦ LIBER ✦

Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

✍ Scribed by Haiying Sun; Gaddam Bapu Reddy; Clifford George; Emmanuelle J. Meuillet; Margareta Berggren; Garth Powis; Alan P. Kozikowski

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 93 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00354-4

No coin nor oath required. For personal study only.

✦ Synopsis

Two 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues were synthesized and shown to be inhibitors of Akt and PI3-K. These compounds were also shown to inhibit the growth of HT-29 human colon cancer cells and MCF-7 human breast cancer cells.

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