𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and biological activity of 3-[(6-chloropyridin-3-yl)methyl]-6-substituted-6,7-dihydro-3H-1,2,3-triazolo[4,5-d]-pyrimidin-7-imines

✍ Scribed by Xiao-Bao Chen; De-Qing Shi

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
321 KB
Volume
45
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

A series of 3‐[(6‐chloropyridin‐3‐yl)methyl]‐6‐substituted‐6,7‐dihydro‐3__H__‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐imines were designed and synthesized via a multi‐step sequence using 2‐chloro‐5‐(chloromethyl)‐pyridine as the starting material. Various primary aliphatic amines, hydrazine and hydrazide reacted with 3 to obtain the cyclization products 4. Their structures were confirmed by ^1^H NMR and elemental analyses, some of them were also confirmed by IR, ^13^C NMR, MS and single crystal X‐ray diffraction. The preliminary bioassay indicated that some of the target compounds 4 displayed moderate to weak fungicidal activity and insecticidal activity.

📜 SIMILAR VOLUMES

ChemInform Abstract: Regioselective Synt
ChemInform Abstract: Regioselective Synthesis of 9-Substituted-8-azaguanines (5-Amino-3- substituted-3,6-dihydro-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one).
✍ M. L. SZNAIDMAN; L. M. BEAUCHAMP 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v