## Abstract Methyl 2,5‐dideoxy‐5‐iodo‐3‐__O__‐pivaloyl‐D‐__erythro__‐pentofur‐anoside (5) was synthesized from 2‐deoxy‐D‐ribose and treated with triethyl phosphite to give the phosphonate 6. Reaction of 6 with silylated 2,4‐dihydroxypyrimidine 7 in the presence of trimethylsilyl trifluoromethanesul
Synthesis and biological activities of 5-trifluoromethyl-5'-azido-2',5'-dideoxyuridine and 5-trifluoromethyl-5'-amino-2',5'-dideoxyuridine
✍ Scribed by Lin, Tai-Shun; Chai, Caroline; Prusoff, William H.
- Book ID
- 127003264
- Publisher
- American Chemical Society
- Year
- 1976
- Tongue
- English
- Weight
- 506 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2623
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## Abstract Methyl 3‐azido‐5‐__O‐tert__‐butyldiphenylsilyl‐2,3‐dideoxy‐D‐__erythro__‐furanoside (3) was coupled with silylated 5‐hydroxymethyluracil (1a) and its C~1~‐C~6~ alkyl ethers 1b–g to give the corresponding protected nucleosides 4a‐g which were deprotected with Bu~4~NF to afford 3‐azido nu