Total synthesis of 4-(d-alanylamino)-2-a
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Violetta Constantinou-Kokotou; Elias A. Couladouros; Minas P. Georgiadis; George
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Article
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1991
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Elsevier Science
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English
β 726 KB
3-Deoxy-DL-prumycin (1) was synthesized from 2-furanmethanol (2-furfuryl alcohol, 2) in eleven steps in 15% total yield. Michael addition of azide anion to 2,3-dideoxy-oqent-2-enopyranos~ulose (3) and reduction in situ of the adduct afforded the key intermediates 5 and 6. Introduction of a second ax