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Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells

โœ Scribed by Chih-Shiang Chang; Ju-Fang Liu; Hwai-Jeng Lin; Chia-Der Lin; Chih-Hsin Tang; Dah-Yuu Lu; Yu-Ting Sing; Li-Yu Chen; Min-Chuan Kao; Sheng-Chu Kuo; Chih-Ho Lai


Book ID
113583250
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
815 KB
Volume
48
Category
Article
ISSN
0223-5234

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Efforts to identify potent small molecule inhibitors of Helicobacter pylori led to the evaluation of 23 3',4',5'-trimethoxychalcone analogues. Some of the compounds displayed potent antibacterial activity against H. pylori. Three most active and selective compounds 1, 7, and 13 also showed the bacte