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Synthesis and Biocompatibility of Maleic Anhydride Copolymers: 1. Maleic Anhydride-Vinyl Acetate, Maleic Anhydride-Methyl Methacrylate and Maleic Anhydride-Styrene

✍ Scribed by Spridon, Daniela; Panaitescu, Luminita; Ursu, Daniel; Uglea, Constantin V.; Popa, Iuliana; Ottenbrite, Raphael M.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 477 KB
Volume: 43
Category: Article
ISSN: 0959-8103
DOI: 10.1002/(sici)1097-0126(199706)43:2<175::aid-pi734>3.0.co;2-i

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✦ Synopsis

A series of maleic anhydride (MA)Èvinyl acetate (VA), MAÈmethyl methacrylate (MM) and MAÈstyrene (S) copolymers were prepared and characterized. By employing various amounts of initiator, MAÈVA, MAÈMM and MAÈS copolymers with molecular weights ranging between 18 000 and 219 000 were obtained. The "in vivoÏ and "in vitroÏ tests performed on K562 cellular cultures (human chronic myeloid leukaemia) and also on Westar rats (inoculated with the Walker 256 carcinosarcome) showed that, as a function of the molecular weight, the copolymers synthesized had a 50% in vitro cytotoxicity and a mean tumour regression of a maximum of 68%.

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