✦ LIBER ✦
Synthesis and biochemical properties of oligodeoxynucleotides acylated by the chemically stable 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5′ or 3′ terminus
✍ Scribed by Ken Yamada; Haruhiko Taguchi; Akihiro Ohkubo; Kohji Seio; Mitsuo Sekine
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 419 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Oligodeoxynucleotides acylated with a 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5 0 or 3 0 terminus were synthesized according to the general method used for DNA synthesis. The acylated DNA oligomers could be easily purified due to the high lipophilicity of the TMSBz group and showed enhanced hybridization ability and resistance to exonucleases.