✦ LIBER ✦

Synthesis and Bioactivity of Some New 2-(Alkoxy carbonyl alkyl)-6-bromo-3,4-dihydro-3-(α-methyl benzyl)-2-oxo-benzo[e] [2H-1,3,2-oxazaphosphinine] Derivatives

✍ Scribed by K. SRINIVASULU; K. SURESH KUMAR; B. HARI BABU; M. F. STEPHEN BABU; C. NAGA RAJU; C. SURESH REDDY

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 71 KB
Volume: 27
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.200990135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Synthesis of some new 2‐(alkoxy carbonyl alkyl)‐6‐bromo‐3,4‐dihydro‐3‐(α‐methyl benzyl)‐2‐oxo‐3‐benzo‐ [e][2__H__‐1,3,2‐oxazaphosphinine] derivatives was accomplished through a two step process, which involves the condensation of 2‐[(α‐methylbenzyl amino)methyl]‐4‐bromophenol (1) with phosphorus oxychloride in equimolar quantities in the presence of triethylamine in dry toluene in 50–55 °C producing the corresponding intermediate (2), and subsequent reaction with the amino acid alkyl ester in dry tetrahydrofuran in the presence of triethylamine at different temperatures. They exhibited significant antibacterial and fungal activity.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Bioac

ChemInform Abstract: Synthesis and Bioactivity of Some New 2-(Alkoxy carbonyl alkyl)-6-bromo-3,4-dihydro-3-(α-methyl benzyl)-2-oxobenzo[e][2H-1,3,2-oxazaphosphinine] Derivatives.

✍ K. Srinivasulu; K. Suresh Kumar; B. Hari Babu; M. F. Stephen Babu; C. Naga Raju; 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 20 KB

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Activity of 6-Alkyl/Chloro-3-{4-(6-alkyl/chloro-2H-benzo[e] [1,3]oxazin-3(4H)-yl)phenyl}-3,4-dihydro-2H-benzo[e][1,3]oxazines.

✍ Ramaiyan Manikannan; Shanmugam Muthusubramanian 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

A New Synthesis of 4-Alkyl/Aryl-5,6-dihy

A New Synthesis of 4-Alkyl/Aryl-5,6-dihydro-2H-pyrano[3,2-c]quinoline-2,5-diones and Molecular Rearrangement of Their 3-Bromo Derivatives to 2-Alkyl/Aryl-4-oxo-4,5-dihydrofuro[3,2-c]quinoline-3-carboxylic Acids.

✍ Antonin Klasek; Kamil Koristek; Petr Sedmera; Petr Halada 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 121 KB 👁 1 views

ChemInform Abstract: New Findings in the

ChemInform Abstract: New Findings in the Alkylation and N-Deprotection of (4S)-4-Methyl-2-benzyl-2,4-dihydro-1H-pyrazino [2,1-b]quinazoline-3,6-diones.

✍ F. L. BUENADICHA; M. T. BARTOLOME; M. J. AGUIRRE; C. AVENDANO; M. SOELLHUBER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 41 KB 👁 2 views

ChemInform Abstract: A Practical Synthes

ChemInform Abstract: A Practical Synthesis of N-(4-Isopropyl-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo [1,4]oxazines-6-carbonyl)guanidine Methanesulfonate (KB-R9032) Utilizing Potassium Fluoride—Alumina Catalyzed N-Alkylation.

✍ T. YAMAMOTO; M. HORI; I. WATANABE; H. TSUTSUI; S. IKEDA; H. OHTAKA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

ChemInform Abstract: Synthesis and Quant

ChemInform Abstract: Synthesis and Quantitative Structure—Activity Relationships of N-(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonyl)guanidines as Na/H Exchange Inhibitors.

✍ Takeshi Yamamoto; Manabu Hori; Ikuo Watanabe; Hisayoshi Tsutsui; Kengo Harada; S 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views