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Synthesis and Bioactivities of Paclitaxel Analogues with a Cyclopropanated Side-Chain.

โœ Scribed by Changhui Liu; Markus Tamm; Marcus W. Noetzel; Armin de Meijere; Jennifer K. Schilling; David G. I. Kingston

Publisher
John Wiley and Sons
Year
2003
Weight
11 KB
Volume
34
Category
Article
ISSN
0931-7597

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A novel type of cyclic opioid peptide analogue, cyclo[N epsilon,N epsilon'-carbonyl-D-Lys2,Lys5]enkephalinamide, was prepared from a linear precursor peptide. The peptide was synthesized on the Merrified resin and also by a combination of the solid-phase technique and the classical method in solutio