Synthesis and binding properties of cyclodextrin trimers

✍ Scribed by David K Leung; Joshua H Atkins; Ronald Breslow

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 89 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01200-x

✦ Synopsis

A series of cyclodextrin trimers and dimers were prepared and examined as binders for appropriate trimeric and dimeric aminoacid amides. Tritopic binding was stronger than ditopic binding, although the free energies were not strictly additive. Such trimers are attractive prospects for the binding of polypeptides and proteins.