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Synthesis and base-mediated dehydrochlorination of 6-chloro-7,8-dihydro-9-(4-methylbenzyl)-2-(trifluormethyl)purine

✍ Scribed by Kelley, James L.; Linn, James A.


Book ID
127173183
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
323 KB
Volume
51
Category
Article
ISSN
0022-3263

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## Abstract Two conformationally constrained tropane derivatives were prepared as rigid nicotinic acetylcholine receptor ligands. A palladium catalyzed intramolecular α‐arylation reaction was employed to generate the tricyclic compounds in good yields from __N__‐(bromo‐chloropyridylmethyl)‐8‐azabic