A synthetic route to stable-isotope-substituted L-phenyl-synthesized from both aromatic precursors by initial conversion into sodium phenylpyruvate and subsequent alanine is presented, which allows the introduction of 13 C, 15 N, and deuterium labels at any position or combination of transformation
Synthesis and applications of isotopically labelled compounds 1994
β Scribed by E. Anthony Evans
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- French
- Weight
- 80 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
ISBN 0 471 95143 9 Price (UK): β¬125 This text is the Proceedings of the Fifth International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds held at Strasbourg, France 20-24 June 1994 organised by the International Isotope Society.
The main part of the book comprises the 161 Papers containing approximately 1216 references, presented at this Symposium, including the 3 Plenary Lectures, and all given by experts in the field of isotopes. A wide range of topics is
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L-[1.2-13C2, 15N]Serine was prepared from [1,2-13C2, 15N]glycine on a gram scale by the use of the enzyme serine hydroxymethyltransferase. The reaction was monitored by 13C-NMR spectroscopy. This is the first simultaneously 13C- and 15N-labelled serine isotopomer so far reported. Part of the product
Reaction of 3-cyanothiophene with one equivalent of potassium nitrate in concentrated sulphuric acid causes nitration, concurrent with hydrolysis of the nitrile, to give 5-nitrothiophene-3-carboxamide in high yield. Similarly, 2-cyanothiophene gives 4-nitrothiophene-2-carboxamide and 5-nitrothiophen