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Synthesis and Antiviral Properties of Spirocyclic [1,2,3]-Triazolooxazine Nucleosides

✍ Scribed by Dell'Isola, Antonio; McLachlan, Matthew M. W.; Neuman, Benjamin W.; Al-Mullah, Hawaa M. N.; Binks, Alexander W. D.; Elvidge, Warren; Shankland, Kenneth; Cobb, Alexander J. A.


Book ID
125861041
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
766 KB
Volume
20
Category
Article
ISSN
0947-6539

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## Abstract A series of novel 3′‐(alkyl(hydroxy)amino)‐2′‐fluoronucleoside analogs were prepared __via__ conjugate addition of __N__‐methylhydroxylamine to various 2‐fluorobutenolides. The adducts **13a** and **16** were obtained as single isomers under absolute control of stereochemistry. The cruc