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Synthesis and antiviral evaluation of some carbonucleoside analogues

✍ Scribed by Miriam A. Martins Alho; Maria I. Errea; Vanesa L. Sguerra; Norma B. D'Accorso; Laura B. Talarico; Cybele C. García; Elsa B. Damonte

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
68 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

1,2‐O‐Isopropylidene‐α‐L‐threofuranosyl heterocyclic derivatives were synthesized from 1,2‐O‐iso‐propylidene‐α‐D‐xilopentadialdo‐1,4‐furanose and tested for antiviral activity against herpes simplex virus type 1, dengue virus type 2 and Junin virus. For comparative propose, the antiviral activity of some of their pyranosyl analogues were also tested. The furanosyl derivatives showed to be moderate inhibitors of Junin virus and, in general, proved to be more effective than the pyranosyl analogues.

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