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Synthesis and antiviral effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted guanosine derivatives

✍ Scribed by Tina Persson; Salo Gronowitz; Anna-Britta Hörnfeldt; Nils Gunnar Johansson

Book ID
103992160
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
567 KB
Volume
3
Category
Article
ISSN
0968-0896

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✦ Synopsis

2-(2"-and 3"-Thienyl)adenosine and the corresponding furyl derivatives were prepared through Pd(0)-catalyzed coupling of 2',3',5'-tri-O-(t-butyldimethylsilyl)-2-iodoadenosine with the appropriate tributyltin derivatives followed by deprotection. Preparation of the 8-(2"-and 3"-thienyl)guanosines and 8-(2"-and 3"-furyl)guanosines followed a similar mute. Antiviral properties of these compounds and the related 2,6-diaminopurine ribofuranosides were of no pharmacological interest.

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