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Synthesis and Antiviral Activity of Novel Fluorinated 2′,3′-Dideoxynucleosides.

✍ Scribed by Piyush Kumar; Kazue Ohkura; Jan Balzarini; Erik De Clercq; Koh-ichi Seki; Leonard I. Wiebe

Publisher
John Wiley and Sons
Year
2004
Weight
184 KB
Volume
35
Category
Article
ISSN
0931-7597

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✍ Motawia, Mohammed S. ;El-Torgoman, Abdel Moneim ;Pedersen, Erik B. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 547 KB

## Abstract The trimethylsilyated 6‐dimethylaminopurine 1 was coupled with the 2′,3′‐dideoxyribose derivatives 2a, b and 7 by using trimethylsilyl triflate as catalyst to yield the corresponding nucleosides 3a, b, 4a, b and 8, which were appropriately deprotected to give the desired nucleosides 5a,