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Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres

✍ Scribed by Rocheblave, Luc; Bihel, Frédéric; De Michelis, Céline; Priem, Ghislaine; Courcambeck, Jérôme; Bonnet, Brice; Chermann, Jean-Claude; Kraus, Jean-Louis


Book ID
126107247
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
40 KB
Volume
45
Category
Article
ISSN
0022-2623

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Synthesis and anti HIV-1 activity of new
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New pyridobenzo-and dipyridothiadiazepindioxides 3-5 and two isomers 13-14 were synthetized and their anti HIV-1 activity and the cytotoxicity were evaluated in vitro. A good antiviral activity was shown by pyridobenzothiadiazepindioxides 4, compound 4a being the best. The human immunodeficiency vi