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Synthesis and Antiviral Activity of Ethidium−Arginine Conjugates Directed Against the TAR RNA of HIV-1

✍ Scribed by Peytou, Valérie; Condom, Roger; Patino, Nadia; Guedj, Roger; Aubertin, Anne-Marie; Gelus, Nathalie; Bailly, Christian; Terreux, Raphaël; Cabrol-Bass, Daniel

Book ID
120351205
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
574 KB
Volume
42
Category
Article
ISSN
0022-2623

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## Abstract Replication of human immunodeficiency virus type 1 (HIV‐1) requires specific interactions of the Tat protein with the transactivation responsive region (TAR) RNA. Tat‐TAR RNA Interaction is mediated by a short arginine‐rich domain of the protein. Disruption of this interaction could, in