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Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

✍ Scribed by Aesop Cho; Oliver L. Saunders; Thomas Butler; Lijun Zhang; Jie Xu; Jennifer E. Vela; Joy Y. Feng; Adrian S. Ray; Choung U. Kim


Book ID
113496762
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
363 KB
Volume
22
Category
Article
ISSN
0960-894X

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4-aza-7,9-dideazaadenosine, a new cytoto
✍ Shirish A. Patil; Brian A. Otter; Robert S. Klein 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 323 KB

The first synthesis of M , the pyrrolo[2,1-fl[1.2,4]triazinc C-nucleoside congener of adenosine is described. The key intexmediate ribofuranosyl pyrmle 4 is obtained by the direct C-ribosylation of pyrrolemagnesiumbromide with 2,3,5-t& 0-benzyl ribose followed by an acid-catalyzed dehydration. Vilsm