Synthesis of 3′-azido-3′-deoxythymidine
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Dagmara Baraniak; Karol Kacprzak; Lech Celewicz
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Article
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2011
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Elsevier Science
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English
⚖ 265 KB
Novel nucleoside-Cinchona alkaloid conjugates were synthesized using 'click' chemistry approach based on the copper(I) catalyzed Huisgen azide-alkyne cycloaddition. Two series of conjugates were prepared employing 3 0 -azido-3 0 -deoxythymidine (AZT) as the azide component and the four 10,11-didehyd