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Synthesis and antiviral activity of 3′-azido-3′-deoxythymidine triphosphate distearoylglycerol: a novel phospholipid conjugate of the anti-HIV agent AZT

✍ Scribed by G.M.T. van Wijk; K.Y. Hostetler; E. Kroneman; D.D. Richman; C.N. Sridhar; R. Kumar; H. van den Bosch


Book ID
107740322
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
667 KB
Volume
70
Category
Article
ISSN
0009-3084

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Synthesis of 3′-azido-3′-deoxythymidine
✍ Dagmara Baraniak; Karol Kacprzak; Lech Celewicz 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 265 KB

Novel nucleoside-Cinchona alkaloid conjugates were synthesized using 'click' chemistry approach based on the copper(I) catalyzed Huisgen azide-alkyne cycloaddition. Two series of conjugates were prepared employing 3 0 -azido-3 0 -deoxythymidine (AZT) as the azide component and the four 10,11-didehyd