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Synthesis and antiviral activity against tobacco mosaic virus and 3D-QSAR of α-substituted-1,2,3-thiadiazoleacetamides

✍ Scribed by Wei-Guang Zhao; Jian-Guo Wang; Zheng-Ming Li; Zhao Yang

Book ID
108074040
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
218 KB
Volume
16
Category
Article
ISSN
0960-894X

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✍ Wei Guang Zhao; Zheng Ming Li; Zhao Yang 📂 Article 📅 2003 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 78 KB

## Abstract The annelation of 1,2,3‐thiadiazole rings was accomplished by the reaction of __N__‐acylhydrazone **2a** bearing an adjacent α‐methyl with thionyl chloride to give α‐chloro‐__N__‐methyl‐1,2,3‐thiadiazole‐4‐acetamide **4** and was demonstrated by the X‐ray crystal structure of its deriva