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Synthesis and Antitumour Effect of the Melanogenesis-based Antimelanoma Agent N-Propionyl-4-S-cysteaminylphenol

โœ Scribed by Manju Tandon; Panakkezhum D Thomas; Mohammed Shokravi; Shradha Singh; Satinder Samra; Daniel Chang; Kowichi Jimbow


Book ID
119407629
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
413 KB
Volume
55
Category
Article
ISSN
0006-2952

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Phenolic melanin precursors can be utilized for the development of anti-melanoma agents. The sulphur homologue of tyrosine, 4-S-cysteinylphenol (CP) and its decarboxylation product, 4-S-cysteaminylphenol (CAP) were shown to be substrates of melanoma tyrosinase, forming melanin-like pigment. Both, bu

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This study reports the synthesis of "C-labelled N-acetyl-4-S-cysteaminylphenol (['4C]N-Ac-4-S-CAP), a potent melanocytotoxic and anti-melanoma agent. A reaction of [U-'4C]phenol with NH2CHZCH2S+ cation in HBr solution was used for the synthesis of (4-S-cysteaminyl['4C]pheno1['4C]4-S-CAP). The excess