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Synthesis and Antitumoral Activity of Gelatin/Polyoxometalate Hybrid Nanoparticles

✍ Scribed by Rui Guo; Yuan Cheng; Dan Ding; Xiaolin Li; Leyang Zhang; Xiqun Jiang; Baorui Liu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
485 KB
Volume
11
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Surfactant‐free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM‐based pharmaceutical agents. magnified image

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