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Synthesis and antitumor activity of novel α-aminophosphonates from diterpenic dehydroabietylamine

✍ Scribed by Xiaoping Rao; Zhanqian Song; Ling He

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
108 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

A series of novel α‐aminophosphonates were synthesized from diterpenic dehydroabietylamine, and their structures were characterized by IR, ^1^H NMR, and ^31^P NMR spectroscopy. Their antitumor activities against SMMC7721 liver cancer cells were evaluated by the MTT method. Compounds 4 and 6 exhibited higher activities even at very low concentrations, and the inhibition ratios reached 75% and 79% at 0.1 µM, respectively. The inhibition ratio of compound 9 reached 99% after 72‐h incubation. α‐Aminophosphonates with a fluorine atom and a nitro group fused to the benzene ring exhibited higher activities. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:512–516, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20471

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