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Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers: Discovery of BMS-184476

โœ Scribed by Altstadt, Thomas J.; Fairchild, Craig R.; Golik, Jerzy; Johnston, Kathy A.; Kadow, John F.; Lee, Francis Y.; Long, Byron H.; Rose, William C.; Vyas, Dolatrai M.; Wong, Henry; Wu, Mu-Jen; Wittman, Mark D.

Book ID
127390067
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
92 KB
Volume
44
Category
Article
ISSN
0022-2623

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ChemInform Abstract: Synthesis and Antit
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Synthesis and Biological Activity of C-6
Synthesis and Biological Activity of C-6 and C-7 Modified Paclitaxels
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AbstractรStructure modiยฎcation of paclitaxel at the C-6 and C-7 positions has been achieved using the readily available intermediate 6ahydroxy-7-epipaclitaxel (2). While a single diastereomer of the cyclic sulยฎte of 2 was prepared at lower temperature, both diastereomers were obtained at room temper