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Synthesis and antitumor activity of des-AB analogue of steroidal saponin OSW-1

✍ Scribed by Minato, Daishiro; Li, Bozhi; Zhou, Dejun; Shigeta, Yasumi; Toyooka, Naoki; Sakurai, Hiroaki; Sugimoto, Kenji; Nemoto, Hideo; Matsuya, Yuji

Book ID
120611670
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
428 KB
Volume
69
Category
Article
ISSN
0040-4020

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## Abstract The estrane analogue of OSW‐1, a potent antitumor natural saponin, was efficiently synthesized from estrone in 12 steps. The cytostatic activity of the compound against several human malignant tumor cells was examined and compared to those of the natural OSW‐1 and cisplatin, the results