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Synthesis and antitumor activity of bis-platinum complexes varying in the nature of the bridging diamine linker group.

โœ Scribed by J.D. Hoeschele; A.J. Kraker; A.D. Sercel; H.D.H. Showalter; W.L. Elliott; N.P. Farrell

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
74 KB
Volume
43
Category
Article
ISSN
0162-0134

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The reaction of Pd(Me,en)Cl, (Me,en =N,N,iV',N'-tetramethylethylenediamine) with inosine and 5'-inosine monophosphate was studied as a function of chloride concentration and pH. Evidence for the formation of a 1:l complex with these nucleophiles is presented, and the kinetic data indicate that Pd(Me