Synthesis and antituberculosis activity of new fatty acid amides

✍ Scribed by Caroline Da Ros Montes D’Oca; Tatiane Coelho; Tamara Germani Marinho; Carolina Rosa Lopes Hack; Rodrigo da Costa Duarte; Pedro Almeida da Silva; Marcelo Gonçalves Montes D’Oca

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 931 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.06.149

✦ Synopsis

acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H 37 Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 lg/mL for resistance strains.