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Synthesis and antitubercular activity of nucleoside analogs based on L-ascorbic acid and bases

✍ Scribed by R. P. Tripathi; Namrata Dwivedi; Nimisha Singh; Mridul Misra

Publisher
Springer-Verlag
Year
2007
Tongue
English
Weight
251 KB
Volume
17
Category
Article
ISSN
1054-2523

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## Abstract A variety of lipophilic 2‐oxoamides containing sulfonamide analogs of γ‐amino acids as well as acyl sulfonamides of γ‐aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA~2~ and GVIA iPLA~2~ as well as secreted GV sPLA~2~ was evaluated. The sulfonamide gr