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Synthesis and antiprotozoal activity of naphthofuranquinones and naphthothiophenequinones containing a fused thiazole ring

✍ Scribed by Ricardo A. Tapia; Luz Alegria; Carlos D. Pessoa; Cristian Salas; Manuel J. Cortés; Jaime A. Valderrama; Marie-Elisabeth Sarciron; Félix Pautet; Nadia Walchshofer; Houda Fillion

Book ID
108479333
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
293 KB
Volume
11
Category
Article
ISSN
0968-0896

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Synthesis and Antileishmanial Activity of Indoloquinones Containing a Fused Benzothiazole Ring
✍ Ricardo A. Tapia; Yolanda Prieto; Félix Pautet; Monique Domard; Marie-Elizabeth 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB

Pyrazinoindoloquinone 6 was synthesized by alkylation of ethyl 4,7-dimethoxyindole-2-carboxylate (1), followed by cyclization of the N-bromoethyl derivative 2b in the presence of ammonia. Oxidative demethylation of 2b and of the oxopyrazinoindole 3 with silver(II) oxide furnished quinones 5b and 6.