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Synthesis and antiproliferative evaluation of new aryl substituted pyrido[3′,2′:5,6]thiopyrano[4,3-c]pyrazoles

✍ Scribed by G. Primofiore; A. M. Marini; S. Salerno; F. Da Settimo; D. Bertini; L. Dalla Via

Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
97 KB
Volume
42
Category
Article
ISSN
0022-152X

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✦ Synopsis

The preparation and the cytotoxic properties of new derivatives of the planar pyrido [3',2':5,6]thiopyrano-[4,3-c]pyrazole system, carrying an arylic side group in the 1 or 2 positions, are described. The novel substituted derivatives were obtained by reaction of suitable arylhydrazines with the appropriate key intermediate 3-hydroxymethylene-2,3-dihydrothiopyrano[2,3-b]pyridin-4(4H)-ones. Moreover the preparation was reported of the 2-carboxamidophenyl derivatives, which was accomplished from the previously obtained pyrido [3',2':5,6]thiopyrano[4,3-c]pyrazole nucleus, by reaction with phenylisocyanate. All the new compounds were evaluated for their antiproliferative ability, by an in vitro assay on human tumor cell lines (HL-60 and HeLa).

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