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Synthesis and antimycotic properties of 1-(2-alkyl-2-phenylethyl)-1H-imidazoles

✍ Scribed by Heeres, J.; Backx, L. J. J.; Van Cutsem, J. M.

Book ID: 126184792
Publisher: American Chemical Society
Year: 1976
Tongue: English
Weight: 767 KB
Volume: 19
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00231a013

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## Abstract The three‐component reaction of (__R__)‐ or (__S__)‐1‐phenylethylamine (**6**), formaldehyde, and an __α__‐(hydroxyimino) ketone **5**, __i.e.__, 3‐(hydroxyimino)butan‐2‐one (**5a**) or 2‐(hydroxyimino)‐1,2‐diphenylethanone (**5b**), yields the corresponding enantiomerically pure 1‐(1‐p