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Synthesis and Antimicrobial Evaluation of Novel Platensimycin Analogues

✍ Scribed by Eva Plesch; Franz Bracher; Jürgen Krauss


Book ID
112002486
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
178 KB
Volume
345
Category
Article
ISSN
0365-6233

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## Abstract **Epimerization and stapling in one pot**: A facile synthesis of an oxazinidinyl analogue of the antibiotic platensimycin is presented. Key steps of this work are a novel dynamic ring‐closing metathesis (RCM) that involves a base‐catalyzed epimerization followed by a tandem Ru‐catalyzed