Synthesis and antimicrobial evaluation of new 1-{[4-(4-Halogenophenyl)-4H-1,2,4- triazol-3-yl]sulfanyl}acetyl-4-substituted thiosemicarbazides and products of their cyclization

✍ Scribed by Nazar Trotsko; Jakub Król; Agata Siwek; Monika Wujec; Urszula Kosikowska; Anna Malm

• Book ID: 102234602
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 121 KB
• Volume: 23
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.20758

✦ Synopsis

Abstract

By the reaction of hydrazides of 4‐(4‐halogenophenyl)‐4H‐1,2,4‐triazol‐3‐yl‐sulfanyl acetic acid with isothiocyanate, 1‐acyl‐4‐substituted thiosemicarbazide derivatives (7–19) were obtained. The cyclization of compounds (7–19) in the presence of 2% NaOH led to the formation of compounds (20–26) containing two 1,2,4‐triazole rings connected by a methylenesulfanyl group. The new compounds were tested for their in vitro antimicrobial activity. Some of the tested compounds (9, 12, 18, 21, 22) showed activity against the reference strains of Gram‐positive bacteria with the MIC (minimal inhibitory concentration) = 125 to >1000 μg/mL. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:117–121, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20758