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Synthesis and antimicrobial activity of some new N-(substituted phenyl)-N′-[2,3-dihydro-2-oxido-3-(4′-fluorophenyl)-1H-(1,3,2)benzoxazaphosphorin 2-yl]ureas

✍ Scribed by P. Haranath; V. Sreedhar Kumar; C. Suresh Reddy; C. Naga Raju; C. Devendranath Reddy

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 331 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440214

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✦ Synopsis

Abstract

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Substituted benzoxazaphosphorin 2‐yl ureas were synthesized by reacting 2‐(4‐fluoro‐phenylamino)‐methylphenol (4) with different carbamidophosphoric acid dichlorides (3) in the presence of triethylamine in dry toluene at 45‐50 °C and characterized by spectral data. These compounds were found to possess good antimicrobial activity.

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## Abstract __N__‐Substituted N′‐[6‐methyl‐2‐oxido‐1,3,2‐dioxaphosphinino(5,4,‐b)pyridine‐2‐yl]ureas have been accomplished by condensation of equimolar quantities of chlorides of various carbamidophosphoric acids (**__3__**) with 3‐hydroxyl‐6‐methyl‐2‐pyridinemethanol (lutidine diol) (**__4__**) i