✦ LIBER ✦

Synthesis and antimicrobial activity of some methyl-2-[N-coumarin-6′-yl]-3-oxo-2,3-dihydro-1H-isoindolone-5-carboxylates

✍ Scribed by Aabid Ali Mir; Vinata V. Mulwad; G. K. Trivedi

Book ID: 102342985
Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 164 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.274

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

N‐substituted furylmethylimines are prepared by condensing 6‐aminocoumarins with furfural, these on sodium borohydride reduction afford N‐[coumarin‐6′‐yl]‐2‐furylamines. Intramolecular [4+2] cycloaddition of these amines with maleic anhydride results into 3‐[N‐coumarin‐6′‐yl]‐4‐oxo‐10‐oxa‐3‐azatricyclo[5.2.1.0^1.5^]dec‐8‐ene‐6‐carboxylic acids 4a, 4b, 4c. The [4+2] cycloadducts on p‐toluene sulphonic acid treatment followed by esterification yield the titled compounds. Compound 5a, 5b, 5c was also reduced to isoindolone alcohol 7a, 7b, 7c by sodium borohydride in the presence of a base. All the compounds have been tested in vitro for their antimicrobial activity against gram‐positive bacteria Bacillus subtilis, Staphylococcus aureus, one gram‐negative bacteria, Escherichia coli, and one fungal strain Candida albicans at 100 μg/mL concentration. J. Heterocyclic Chem., 2010.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Antim

ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Methyl-2-[N-coumarin-6′-yl] -3-oxo-2,3-dihydro-1H-isoindolone-5-carboxylates.

✍ Aabid Ali Mir; Vinata V. Mulwad; G. K. Trivedi 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 40 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis of Biologically Active N-[Coum

Synthesis of Biologically Active N-[Coumarin-6-yl] -3-methyl-5-(hydroxy/methyl/4-hydroxy-8-methylcoumarin-3-yl)pyrazoles and [2.3.1]-Bicyclo-N-[coumarin-6-yl]-1,2-diazepines.

✍ B. P. Choudhari; V. V. Mulwad 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

One-Pot Synthesis of (1,2,3-Triazolyl)me

One-Pot Synthesis of (1,2,3-Triazolyl)methyl 3,4-Dihydro-2-oxo-1 H -pyrimidine-5-carboxylates as Potentially Active Antimicrobial Agents

✍ Dabiri, Minoo; Salehi, Peyman; Bahramnejad, Mahboubeh; Koohshari, Majid; Aliahma 📂 Article 📅 2014 🏛 John Wiley and Sons 🌐 German ⚖ 197 KB

Synthesis and Crystal Structures of Meth

Synthesis and Crystal Structures of Methyl 3-(Benzoylamino)-6-methyl-2-oxo-2H-pyran-5-carboxylate andN-[5-(3,4-Dimethoxyphenyl)-6-methyl-2-oxo-2H-pyran-3-yl]benzamide

✍ Krištof Kranjc; Amadej Juranovič; Marijan Kočevar; Franc Perdih 📂 Article 📅 2012 🏛 Springer 🌐 English ⚖ 542 KB

ChemInform Abstract: Synthesis and Antim

ChemInform Abstract: Synthesis and Antimicrobial Screening of 5-(4,7-Dimethyl-2-oxo-2H-benzopyran-6-ylazo) -2-methyl-6-morpholin-4-yl-2,3-dihydro-3H-pyrimidin-4-one and 5-(4,7-Dimethyl-2-oxo-2H-benzopyran-6-ylazo) -2-methyl-6-piperidin-1-yl-2,3-dihydro-3H-pyrimidin-4-one.

✍ Vinata V. Mulwad; Sagar A. Mayekar 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Synthesis and Antim

ChemInform Abstract: Synthesis and Antimicrobial Evaluation of Some New 2-(6-Oxo-5,6-dihydro[1,3]thiazolo [3,2-b]-2-aryloxymethyl-1,2,4-triazol-5-yl)-N-arylacetamides.

✍ Prajwal L. Lobo; Boja Poojary; Kumsi Manjunatha; Nalilu Suchetha Kumari 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views