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Synthesis and antimicrobial activity of some heterocyclic 2,6-bis(substituted)-1,3,4-thiadiazolo-, oxadiazolo-, and oxathiazolidino-pyridine derivatives from 2,6-pyridine dicarboxylic acid dihydrazide

✍ Scribed by Said A. S. Ghozlan; Mohammed A. Al-Omar; Abd El-Galil E. Amr; Korany A. Ali; Ahmed A. Abd El-Wahab

Publisher: Journal of Heterocyclic Chemistry
Year: 2011
Tongue: English
Weight: 181 KB
Volume: 48
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.690

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✦ Synopsis

Abstract

In this work, we report on the synthesis and preliminary biological activity screening of several heterocyclic derivatives 2, 3, 4, 5, 6, 7, 8, 9, 10, 10a, 10b, 11, 11a, 11b, 12, 12a, 12b, 13, 13a, 13b, 14, 15 based on __N__2′,__N__6′‐diphenylthiosemi‐carbazide pyridine‐2,6‐dicarbohydrazide 2, which has been obtained from the corresponding dihydrazide 1. The biological screening showed that many of these compounds have good antimicrobial activities. The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. J. Heterocyclic Chem., (2011).

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