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Synthesis and antimicrobial activity of novel spirocompounds with pyrazolone and pyrazolthione moiety

✍ Scribed by Madhukar S. Chande; Pravin A. Barve; Vijay Suryanarayan

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 349 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440108

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✦ Synopsis

Abstract

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The paper focuses on the utility of 2‐pyrazoline‐5‐ones and 2‐pyrazoline‐5‐thiones as active Michael donors for the synthesis of novel spirocyclohexanone derivatives. The sulphur containing compounds when screened for antimicrobial activity showed promising inhibition of S. Typhi, S Aures and E Coli bacteria.

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