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Synthesis and antimicrobial activity of new C-furyl glycosides bearing substituted 1,3,4-oxadiazoles

✍ Scribed by Wael A. El-Sayed; Hebat-Allah S. Abbas; Ashraf M. Mohamed; Adel A.-H. Abdel-Rahman

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
150 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

New 2,5‐disubstituted 1,3,4‐oxadiazole derivatives bearing C‐furyl glycoside moieties and their sugar hydrazone as well as their per‐O‐acetyl derivatives were synthesized starting from ethyl 2‐[5‐(3,4‐dihydroxytetrahydrofuran‐2‐yl)‐2‐methylfuran‐3‐yl]‐2‐oxoacetate. Heterocyclization of the sugar hydrazones using acetic anhydride afforded the corresponding oxadiazoline acyclic C‐nucleosides. The antimicrobial activity evaluation showed that many of the synthesized compounds revealed moderate to high antimicrobial activity. J. Heterocyclic Chem., (2011)

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Synthesis and antimicrobial activity of some novel substituted 1,2,4-triazoles bearing 1,3,4-oxadiazoles or pyrazoles
✍ Mehdi Kalhor; Akbar Mobinikhaledi; Akbar Dadras; Maryam Tohidpour 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 100 KB

## Abstract Several derivatives of substituted 1,2,4‐triazole bearing the pyrazole (or oxadiazole) ring were synthesized __via__ the reaction of 2,4‐dihydro‐4‐benzyl‐5‐(isomeric pyridyl)‐3H‐1,2,4‐triazole‐3‐thione **1a**, **1b**, **1c** with ethyl chloroacetate, hydrazine hydrate, and acetyl aceton