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Synthesis and antimicrobial activity of 5,5′-dimethyl-2-oxido-[1,3,2]-dioxaphos-phorinane-2-yl-amino carboxylates

✍ Scribed by B. Hari Babu; G. Syam Prasad; C. Suresh Reddy; C. Naga Raju

Book ID
102231946
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
123 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Synthesis of several 5,5‐dimethyl‐2‐oxido‐[1,3,2]‐dioxaphosphorinane‐2‐yl‐amino carboxylates (4a–j) was accomplished through a two‐step process. This involves prior preparation of the intermediate monochloride (2), 2‐chloro‐5,5‐dimethyl [1,3,2]dioxaphosphorinane‐2‐oxide and its subsequent reaction with various amino acid esters (3a–j) in dry tetrahydrofuran in the presence of triethyl amine at room temperature. They were characterized by elemental analysis, IR, ^1^H, ^13^C, ^31^P NMR, and mass spectral data. Their antifungal and antibacterial activity is also evaluated. Majority of these compounds exhibited moderate antimicrobial activity in the assay. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:256–260, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20426

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