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Synthesis and antihypoxic activity of 1,2,4-triazoles, 1,3-dithiane-1,1,3,3-tetraoxides, and 1,4-benzothiazin-3(4H)-one

โœ Scribed by V. M. Neplyuev; I. S. Morozov; N. N. Samoilov; I. M. Bazavova; A. S. Losev; A. F. Shivanyuk; E. N. Tret'yakova; E. P. Pavlova; M. O. Lozinskii


Book ID
112401428
Publisher
Springer
Year
1992
Tongue
English
Weight
388 KB
Volume
26
Category
Article
ISSN
0091-150X

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Solid-phase combinatorial synthesis of 1
โœ Cheng Leng Lee; Kok Ping Chan; Yulin Lam; Soo Ying Lee ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 82 KB

The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide 2a and 3-nitro-4-sulfanylbenzamide 2b, followed by reduction and cyclization gave 4. Further alkylation and acylation was performed on th