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Synthesis and anticonvulsant activity of 2-iminohydantoins

โœ Scribed by Kwon, Chul Hoon; Iqbal, Muhammad Tahir; Wurpel, John N. D.

Book ID
125972846
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
719 KB
Volume
34
Category
Article
ISSN
0022-2623

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Synthesis and structure activity study o
Synthesis and structure activity study of N-1 substituted (S)-(+)-5-n-propyl-2-iminohydantoins as potential anticonvulsant agents
โœ Ching-Hsin Kung; John N.D. Wurpel; Chul-Hoon Kwon ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 130 KB ๐Ÿ‘ 2 views

A series of (S)-(+)-5-n-propyl-2-iminohydantoins with various N-1 substituents were synthesized and tested for anticonvulsant activity to better understand the structure-activity relationship (SAR) of 2-iminohydantoins. Compounds with N-1 phenoxycarbonyl (2), ethoxycarbonyl (6), t-butoxycarbonyl (7)