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Synthesis and anticancer activity of novel quinoline–docetaxel analogues

✍ Scribed by Chen, Ming; Chen, Hui; Ma, Jiangwei; Liu, Xueying; Zhang, Shengyong

Book ID
125439003
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
317 KB
Volume
24
Category
Article
ISSN
0960-894X

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Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-β-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest