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Synthesis and anticancer activities of fatty acid analogs of podophyllotoxin

โœ Scribed by Jamal Mustafa; Shabana I. Khan; Guoyi Ma; Larry A. Walker; Ikhlas A. Khan

Book ID
107485416
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
225 KB
Volume
39
Category
Article
ISSN
0024-4201

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A series of 11 asparagines substituted on N4 was prepared and evaluated for their ability to inhibit the growth of L5178Y leukemia cell cultures. These cells require an exogenous source of L-asparagine and should be sensitive to an asparagine antimetabolite. The compounds were prepared by reaction o