✦ LIBER ✦

Synthesis and antibacterial screening of new 4-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylthio)methyl)tetrazolo[1,5-a]quinoline derivatives

✍ Scribed by Swapnil S. Sonar; Sandip A. Sadaphal; Rajkumar U. Pokalwar; Bapurao B. Shingate; Murlidhar S. Shingare

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 87 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.340

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✦ Synopsis

Abstract

magnified image A method for the synthesis of previously unknown heterocyclic systems 4‐((5‐(difluoromethoxy)‐1__H__‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinolines derivatives 6 has been developed based on various substitutes 2‐chloroquinoline‐3‐carbaldehydes 1 via the consecutive steps of conversion into tetrazolo[1,5‐a]quinoline‐4‐carbaldehyde 2 on treatment with sodium azide which upon reduction to the corresponding alcohol derivatives 3, conversion to chlorides 4 with thionyl chloride followed by the coupling with 5‐(difluoromethoxy)‐1__H__‐benzo[d]imidazole‐2‐thiol 5. The synthesized titled compounds (6a, 6b, 6c, 6d, 6e) were screened for the antibacterial activity against gram positive and gram negative bacteria. J. Heterocyclic Chem., (2010).

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