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Synthesis and antibacterial evaluation of phosphonic acid analogues of diaminopimelic acid

✍ Scribed by I van Assche; M Soroka; A Haemers; M Hooper; D Blanot; J van Heijenoort


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
978 KB
Volume
26
Category
Article
ISSN
0223-5234

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A general method based on the sequential reactivities of bis-bromocycloalkenes (3-5) is proposed for the preparation of phosphonocycloalkanes (1a/b-3a/b), representing structural constrained analogues of AP4. For the synthesis of an additional congested AP4 analogue (4), an intramolecular cyclopropa