Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3′-fluoro-3′-deoxythymidine and 3′-azido-3′-deoxythymidine
✍ Scribed by Yousef Ahmadibeni; Rakesh Tiwari; Chelsie Swepson; Jui Pandhare; Chandravanu Dash; Gustavo F. Doncel; Keykavous Parang
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 423 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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The new monomer, 5@-O-methacryloyl-3@-azido-3@-deoxythymidine (MAZT), was synthesized by the reaction of methacryloyl chloride and 3@-azido-3@-deoxythymidine (AZT). Poly(MAZT) and copolymers of MAZT with vinyl acetate (VAc) and maleic anhydride (MAH) were synthesized by radical polymerizations. The
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